Avtor/Urednik		Kansky, A; Vodnik, A; Stanovnik, L
Naslov		Serious drug reactions to carbamazepine in oncologic patients after x-ray treatment
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 11, št. 3
Leto izdaje		2002
Obseg		str. 105-9
Jezik		eng
Abstrakt		Carbamazepine is a valuable and widely used drug for treatment and prevention of epileptiform fits and further neurological conditions. Milder general symptoms like dizziness or drowsiness or cutaneous side effects like rashes, pruritus, urticaria, or multiform erythema are not unusual. Sometimes serious cutaneous adverse reactions e.g., Stevens Johnson syndrome, generalized erythroderma or even toxic necrolysis may appear. We report on four cases: in three female patients, who have been operated for malignant brain tumors and were given carbamazepine for prevention of seizures, partial erythroderma developed; the fourth died from toxic epidermal necrolysis. All were treated with x-rays, in the female patients cutaneous manifestations disappeared after systemic treatment with corticosteroids and replacement of carbamazepine with other anticonvulsive drugs.
Deskriptorji		CARBAMAZEPINE BRAIN NEOPLASMS ADULT MIDDLE AGE DERMATITIS, EXFOLIATIVE EXANTHEMA