Avtor/Urednik		Marko, P; Miljkovič, J
Naslov		Amiodarone - induced skin pigmentation
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 11, št. 3
Leto izdaje		2002
Obseg		str. 110-2
Jezik		eng
Abstrakt		In last year a few cases of blue-gray skin pigmentation in photo exposed areas (face and hands) were observed at our department. Because of a chronic myocardiopathy and arrhythmia, all these patients had taken amiodarone 200 mg daily over more than two years. Histopatholologic examination revealed upper and mid-dermal deposits of a yellow-black granular pigment distributed perivascularly in the cytoplasm of dermal macrophages. Special staining demonstrated that this pigment has the characteristics of lipofuscin. The small number of cases reported are probably due to the fact that this side effect of amiodarone is not so rare but frequently unrecognized.
Deskriptorji		AMIODARONE SKIN PIGMENTATION AGED PIGMENTATION DISORDERS