Avtor/Urednik		Peternel, P
Naslov		Novi pristopi k trombolitičnemu zdravljenju venske tromboze
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1991
Obseg		str. 61
Jezik		slo
Abstrakt		The thesis encompasses two studies in which new approaches to treatment of the acute proximal deep vein thrombosis with streptokinase (SK) are described. In the first study the effect of intermittent and continuous SK treatment on recanalization rate and hemostasis tests was investigated. Forty patients were studied. They received randomly either intermittent SK treatment (20 patients, 10 men, 1- women, 19 to 70 years, mean 51 years old) or continuous SK treatment (20 patients, 12 men, 8 women, 22 to 70, men 47 years old). Patients with intermittent treatment were receiving SK 7.5 hours daily in the dose 100 000 U/h and receiving SK as a continuous infusion in the dose 100 000 U/h. In both groups patients were treated three to five days. In all patients plasminogen, alpha-2-antiplasmin, fibrinogen, euglobulin clot lysis time, thrombin time, activated partial thromboplastin time and fibrin(ogen) degradation products were measured twice daily. In intermittently treated patient, 30-40 percent increase above pretreatment value of plasminogen was observed during heparin administration. Similar fluctations were observed for alpha-2-antiplasmin. Plasminogen and alpha-2-antiplasmin were lower in the continously treated group all the time of treatment (p less than 0.01). During the first two days of treatment spontanous plasma fibrinolytic activity on fibrin plates and by lysis of whole plasma clots was observed in 9 patients treated intermittently and in 9 patients treated continuously. Spontaneous fibrinolytic activity was observed in both groups on the first day, but on the second day only in the intermittently treated group. The effect of treatment was evaluated with x-ray venography in the late phase of the disease (three to 33, men 13 months after treatment). Complete recanalization of all affected vessel segments was established in four (22 percent) patients treated intermittently and six (27 percent) treated continuously (not significant).(trunc.)
Deskriptorji		THROMBOPHLEBITIS STREPTOKINASE BANDAGES BLOOD COAGULATION TESTS