Avtor/Urednik		Ðaković-Rode, Oktavija; Ružić-Sabljić, Eva
Naslov		Lyme borelioza - diferencijalno dijagnostičke poteškoće u interpretaciji seroloških rezultata
Prevedeni naslov		Lyme borreliosis - differential diagnostic difficulties in the interpretation of serological results
Tip		članek
Vir		Infektol Glas
Vol. in št.		Letnik 22, št. 2
Leto izdaje		2002
Obseg		str. 45-9
Jezik		cro
Abstrakt		Lyme borreliosis (LB) is a multisystemic inflammatory disease caused by spirochete Borrelia burgdorferi sensu lato. Specific antibody response is influenced by phenotypic characteristics of Borrelia, different antigenic structure, their different geographic distribution, and patient capability to react to infection. Immune response to Borrelia burgdorferi sensu lato deveops relatively late while in some patients it never develops. Immune reposnse in early phase of LB is very similar to immune response of healthy population. Clinical manifestation, detailed anamnesis, and eidemiological data are crucial for making the diagnosis. The majority of patients in late phase of LB have IgG antobody response, which could be followed by IgM also throughout this period of time. Specific borrelial antigens can be detected with Western blot test. In patients with neuroborreliosis, antibodies could be synthesized only intrahealthy. IgG and IgM antibody response can persist for many years after treatment. There is no positive serologic test, which solely could be the indicator of disease activity; even if it demonstrates high antibody titer. If there are no clinical signs of LB, demonstration of reactive antibody response is not the evidence of LB. The diagnosis of LB should be primary based on clinical findings and serologic results should be used only to confirm, and not to make the diagnosis of LB.
Deskriptorji		LYME DISEASE BORRELIA BURGDORFERI ANTIBODIES, BACTERIAL IGG IGM DIAGNOSIS, DIFFERENTIAL