Avtor/Urednik		Štalc, Jurij; Tominc, Uroš
Naslov		Primerjava endotelijske funkcije in magnetnoresonančnih lastnosti žilne stene med bolniki s klasično in dilatativno obliko ateroskleroze
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2002
Obseg		str. 30
Jezik		slo
Abstrakt		Background: Dilatative atherosclerosis is a rare form of degenerative process manifested by arterial aneurysms. The pathogenesis of aneurysm formation is not completely understood, however, involvement of proteolytic degradation of intracellular matrix and smooth muscle cell necrosis are important. It is believed that endothelial dysfunction is involved in dilatative and occlusive atherosclerosis. As a surrogate for estimation of systemic endothelial dysfunction a standardized endothelium-dependent vasodilatation test can be used. Alteration of arterial wall in aneurysm due to smooth muscle cell necrosis and/or matrix degeneration/degradation can be visualized and estimated by high-resolution magnetic resonance imaging (MRI). Aim: The aim of our study was to measure endothelial dysfunction and to identify some structural and morphological characteristics of dilatative atherosclerosis by MRI. Hypotheses: 1. Endothelial function of patients with aneurysms assessed by endothelium-dependent vasodilatation test is more impaired than in patients with classic atherosclerosis. 2. MR signal from the vessel wall of popliteal aneurysm differs from that of atherosclerotic vessel wall; 3. MR signal from the vessel wall of popliteal aneurysm differs in comparison to the signal from nearby non-dilated site. 4. Thickness of the vessel wall at the dilated (aneurysmal) site equals to the thickness of non-dilated site of the same vessel. Methods: We included 12 male patients with popliteal artery aneurysm (age 60,8 +- 12,4 years) (group A) and 9 male patients (age 65,3 +- 9,8 years) with classic atherosclerosis (group K). Endothelial function was estimated by endothelium-dependent vasodilatation test. (Abstract truncated at 2000 characters).
Deskriptorji		ATHEROSCLEROSIS ANEURYSM ENDOTHELIUM, VASCULAR BRACHIAL ARTERY VASODILATION MIDDLE AGE AGED MAGNETIC RESONANCE IMAGING NITROGLYCERIN POPLITEAL ARTERY