Avtor/Urednik		Ukmar, Maja; Moretti, Rita; Torre, Paola; Antonello, Rodolfo M; Longo, Renata; Bana, Antonio; Pozzi-Mucelli, Roberto
Naslov		Cortico-basal ganglionic degeneration: radiological and functional features
Prevedeni naslov		Degeneracija kortikobazalnih ganglijev: radiološke in funkcionalne značilnosti
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 36, št. 4
Leto izdaje		2002
Obseg		str. 297-303
Jezik		eng
Abstrakt		Background. Cortico-basal ganglionic degeneration is a rare degenerative pathology that involves parietal areas and gradually determines frontal involvement. The aim of our work was to describe the main radio- logical findings in this pathology and to evaluate the cortical activation in these patients by f-MRI during simple and complex movements. Patients and methods. We have evaluated eight patients with morphological and functional magnetic res- onance by using a 1.5 T imager. Results. Morphological evaluation: We found an asymmetric perirolandic cortical atrophy in seven pa- tients, a mild hyperintensity in the perirolandic cortex in five patients, a mild atrophy of the basal ganglia in seven patients and, in one, a hypointensity in the lenticular nuclei. In one patient the morphological as- pect was normal. Functional evaluation: The most important aspect was the hypoactivation of the parietal areas during the movement with the affected hand in all the patients. Conclusions. We consider f-MRI a helpful tool for the diagnosis and follow-up of this pathology.
Izvleček		Izhodišča. Degeneracija kortikobazalnih ganglijev je redka degenerativna bolezen, ki prizadene parietalne predele in postopno preide v frontalno prizadetost. Namen študije je bil opisati glavne radiološke značilnosti te bolezni in s funkcionalno magnetno resonančno preiskavo oceniti kortikalno aktivacijo bolnika med enostavnimi in kompleksnimi gibi. Bolniki in metode. Ocenili smo osem bolnikov z morfološko in funkcionalno magnetno resonanco ob uporabi slik posnetih pri 1,5 T.Rezultati. Morfološka ocena: Pri sedmih bolnikih smo našli asimetrično perirolandsko kortikalnoatrofijo, pri petih blago hipersenzitivnost perirolandskega korteksa, pri sedmih blago atrofijo bazalnih ganglijev in pri enem hiposenzitivnost lentikularnega jedra. Pri enem bolniku so bili morfološki aspekti normalni. Funkcionalna ocena: Najpomembnejša je hipoaktivacija parietalnih predelov pri gibih s prizadeto roko, kar smo ugotovili pri vseh bolnikih. Zaključki. Funkcionalna magnetna resonančna preiskava je potencialno koristno orodje pri diagnozi in spremljanju degeneracije kortiko-bazalnih ganglijev.
Deskriptorji		BASAL GANGLIA DISEASES NERVE DEGENERATION MAGNETIC RESONANCE IMAGING MAGNETIC RESONANCE ANGIOGRAPHY FLUORINE RADIOISOTOPES APRAXIA