Avtor/Urednik		Turk, Martina; Plemenitaš, Ana
Naslov		The HOG pathway in the halophilic black yeast Hortea werneckii: isolation of the HOG1 homolog gene and activation of HwHog1p
Tip		članek
Vir		FEMS Microbiol Lett
Vol. in št.		Letnik 216
Leto izdaje		2002
Obseg		str. 193-9
Jezik		eng
Abstrakt		The mitogen-activated protein kinase (MAPK) Hoglp plays an essential role in the yeast hyperosmotic response. A homolog of the HOG1 gene was isolated from the halophilic black yeast Hortaea werneckii encoding a putative 359 amino acid protein, HwHoglp, with high homology to Saccharomyces cerevisiae Hoglp and to other eukaryotic Hoglp homologs. HwHoglp contains a TGY motif within a protein kinase catalytic domain and a C-terminal common docking (CD) motif. Its activation by increased salinity is regulated at the posttranscriptional level. HwHoglp is located on the plasma membrane under nonstress conditions. Upon increased external salinity it is translocated from the membrane, presumably to the nucleus.
Deskriptorji		YEASTS PROTEIN-SERINE-THREONINE KINASES CELL MEMBRANE ASCOMYCETES SIGNAL TRANSDUCTION DNA, FUNGAL BLOTTING, WESTERN OSMOTIC PRESSURE GLYCERIN CLONING, MOLECULAR BASE SEQUENCE BLOTTING, SOUTHERN