Avtor/Urednik		Rozman, Tanja; Štrancar, Katja; Kozjek, Franc
Naslov		Farmakogenomika in razvoj novih zdravil
Prevedeni naslov		Pharmacogenomics and drug development
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 53, št. 1
Leto izdaje		2002
Obseg		str. 17-21
Jezik		slo
Abstrakt		Due to the continuous increase in time and cost of drug development and the considerable amount of resources required by the traditional approach, new technologies in drug development like pharmacogenomics are being introduced. Pharmacogenomics is an emerging discipline that focuses on genetic determinants of drug response at the level of the entire human genome. It is thereby improving our knowledge about the origin of the disease, identifing new therapeutic targets and providing a stronger scientific basis for selecting clinical trial patients as well as optimizing drug therapy on the basis of each patient's genetic constitution.
Izvleček		Čas in stroški, ki so potrebni za razvoj inovativnega zdravila, hitro naraščajo. V želji po povečanju učinkovitosti in uspešnosti razvoja prihaja v zadnjih letih do razmaha novih tehnologij. Farmakogenomika je nova disciplina, ki proučuje celotni humani genom, da bi identificirala in locirala genetske determinante posameznikovega odziva na zdravilo. Farmakogenomske analize omogočajo študij genov, ki so povezani z nastankom bolezni. Proteini, ki jih takšni geni kodirajo, so nove, potencialne tarče za zdravila. Hkrati pa so farmakogenomske analize osnova za izbor pacientov v kliničnih študijah in za terapevtske pristope na podlagi genotipa vsakega posameznika.
Deskriptorji		TECHNOLOGY, PHARMACEUTICAL POLYMORPHISM (GENETICS) DRUG APPROVAL GENOME PARKINSON DISEASE