Avtor/Urednik		Štrancar, Katja; Rozman, Tanja; Kozjek, Franc
Naslov		Genetski polimorfizmi in optimizacija farmakoterapije
Prevedeni naslov		Genetic polymorphism and optimization of drug therapy
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 53, št. 1
Leto izdaje		2002
Obseg		str. 21-7
Jezik		slo
Abstrakt		The person-to-person variability of a drug response is a major problem in clinical practice and in drug development. Genetic polymorphisms in the genes that code for drug-metabolising enzymes, drug receptors, and drug transporters can affect an individual's risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences, thereby providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.
Izvleček		Velika medsebojna raznolikost posameznikov v odzivanju na zdravilo predstavlja enega večjih problemov sodobne medicinske prakse. Zaradi raznolikosti genov, ki nosijo zapis za encime metabolizma, tarčne receptorje in proteine prenašalce zdravil, dano zdravilo ni enako učinkovito in varno za vsakega posameznika. Farmakogenomske študije pospešeno odkrivajo te podedovane razlike in s tem pripravljajo trdno strokovno osnovo za optimizacijo farmakoterapije na osnovi genetskega profila vsakega posameznika.
Deskriptorji		PHARMACOGENETICS POLYMORPHISM (GENETICS) HUMAN GENOME PROJECT TECHNOLOGY, PHARMACEUTICAL CYTOCHROME P-450 PHENOTYPE