Avtor/Urednik		Hojs, Radovan; Ekart, Robert; Dvoršak, Benjamin
Naslov		Atherosclerosis in patients with analgesic nephropathy treated with haemodialysis
Tip		članek
Vir		Nephrology
Vol. in št.		Letnik 7
Leto izdaje		2002
Obseg		str. 272-6
Jezik		eng
Abstrakt		Accelerated atherosclerosis was reported to be associated with chronic analgesic consumption, but most studies were retrospective, and individual findings have almost never been controlled with regard to other atherosclerotic risk factors. Ten haemodialysis patients with analgesic nephropathy (group I) and 19 haemodialysis patients where renal failure was not caused by analgesic nephropathy (group II) were included in the study. All patients were female without diabetes. Using B-mode ultrasonography, we compared intima-media thickness (IMT) in the carotid arteries and plaque occurrence, and their thickness in group I with that in group II. The possible differences in atherosclerotic risk factors in both groups were also investigated. In group I, the average age was 60.2 years, and the average dialysis treatment was 55.7 months. In group II, the average age was 54.6 years, and the average duration of dialysis treatment was 50.4 months. We found no statistically significant difference in the age and duration of dialysis treatment between groups I and II. The IMT values of the carotid arteries (0.97 vs 0.78 mm; P = 0.027) were significantly higher in group I. More patients had plaques in group I (90 vs 57.9%), and the number of plaques (P = 0.037) and their thickness (P = 0.043) were significantly higher in this group. There was no statistically significant difference in the atherosclerotic risk factors between groups I and II. The results indicate that patients with analgesic nephropathy treated with haemodialysis showed advanced atherosclerosis compared with other haemodialysis patients, despite no difference being found in the atherosclerotic risk factors between these patients.
Deskriptorji		KIDNEY FAILURE, CHRONIC ANALGESICS HEMODIALYSIS ATHEROSCLEROSIS CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA CHOLESTEROL TRIGLYCERIDES LIPOPROTEIN(A) PARATHYROID HORMONES HYPERTENSION SMOKING RETROSPECTIVE STUDIES