Avtor/Urednik		Pinter, B; Kocijančič, A; Marc, J; Andolšek, L
Naslov		OC and genetic determinants of bone metabolism
Tip		članek
Vir		In: Bruni V, Dei M, editors. Pediatric and adolescent gynecology. 9th European congress of pediatric and adolescent gynecology; 2002 Dec 2-5; Florence. Roma: CIC Edizioni internazionali,
Leto izdaje		2002
Obseg		str. 293-6
Jezik		eng
Abstrakt		Introduction: We designed a study with the aim to determine whether bone metabolism in young women using low-dose OC is influenced by VDR genotype. Material and methods: In a prospective clinical study 41 healthy women aged 20 - 27 years were included. Twenty-one women of the study group were prescribed an oral contraceptive (30 microg ethynyl estradiol and 150 microg levonorgestrel) and twenty women of the control group a non-hormonal contraceptive or none. Biochemical markers of bone metabolism (bone-specific alkaline phosphatase, osteocalcin, deoxypyridinoline) and VDR genotype, using Bsml endonuclease, were determined. Results: After three months in the study group in the BB genotype subgroup osteocalcin significantly decreased, in the Bb genotype subgroup bone-specific alkaline phosphatase and osteocalcin decreased, and in the bb genotype subgroup no changes were observed. In the control group there were no significant changes in markers of bone metabolism regarding VDR genotype. Conclusion: OC with 30 microg ethynyl estradiol and 150 microg levonorgestrel decrease bone metabolism in women aged 20-27 years with the BB and the Bb genotype, but not in the women with bb VDR genotype.
Deskriptorji		CONTRACEPTIVES, ORAL, HORMONAL BONE AND BONES ALKALINE PHOSPHATASE OSTEOCALCIN PYRIDONES ADULT ESTRADIOL LEVONORGESTREL RECEPTORS, CALCITRIOL POLYMORPHISM, RESTRICTION FRAGMENT LENGTH CREATININE