Avtor/Urednik		Reberšek, Martina
Naslov		Elektrokemoterapija raka dojk
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2003
Obseg		str. 54
Jezik		slo
Abstrakt		Purpose: To determine whether electrochemotherapy with intratumoral application of cisplatin is effective in the treatment of cutaneous tumor lesions of breast cancer, and to compare the efficacy of electrochemotherapy with efficacy of intratumoral application of cisplatin alone. Patients and methods: Patients with metastatic breast cancer, in whom the potentials of standard treatment with surgery, chemotherapy and radiotherapy were exhausted or who refused it, were included into the study. Cutaneous tumor lesions were treated with intratumoral application of cisplatin at a dose calculated according to the volume of lesions followed by the application of electric pulses or only with intratumoral application of cisplatin. The treatment and follow-up of patients were carried out in an out-patient's clinic. The size of tumor lesions was measured with caliper. The volume was calculated according to formula V= a x b x c x pi/6 (where a, b and c were the diameters of lesion). The lesions were photographed before the beginning of treatment and after it.The efficacy of the treatment was evaluated according to adjusted WHO classification. Statistically significant difference (p < 0.05) between both treatment modalities was determined, by chi square analysis. Results: Of 53 cutaneous tumor lesions, 25 were treated with electrochemotherapy, 14 were treated with intratumoral application alone and 14 were controls. In 13 tumor lesions, which were followed only for 2 weeks because of the death of patients, objective, complete and partial responses were seen in 38.5%, 7.7% and 30.8%, respectively. In 12 tumor lesions with the follow-up more than 2 weeks, median follow- up was 5 weeks (range 2-18 weeks). Objective responses were seen in all treated tumor lesions. Complete responses were seen in 33 % with median follow-up of 10 weeks (range 4-16 weeks). Partial responses were seen in 77 % with median follow-up of 5 weeks (range 2-16 weeks). (Abstract truncated at 2000 characters).
Deskriptorji		BREAST NEOPLASMS ELECTROPORATION CISPLATIN DRUG DELIVERY SYSTEMS TREATMENT OUTCOME FOLLOW-UP STUDIES