Avtor/Urednik		Zupan, I; Krhin, B; Zupan, IP; Rakovec, P
Naslov		Impact of systolic atrial function on atrial natriuretic factor during rapid atrial pacing in a canine model
Tip		članek
Vir		In: Tse H-F, Lee KLF, Lau C-P, editors. Clinical cardiac pacing and electrophysiology. Bologna: Monduzzi editore, International proceeding division,
Leto izdaje		2002
Obseg		str. 719-23
Jezik		eng
Abstrakt		The aim of the study was to compare the influence of mechanical remodeling on the increase of atrial natriuretic factor (ANF). 8 dogs were subjected to rapid atrial pacing (RAP) at 400 bpm for I6 days. Left atrial systolic maximal dimension (LA-A) and left atrial appendage peak late emptying velocity (LAA-E) were assessed by echocardiography. Blood samples were taken from the right atriurn and from the peripheral vein. All measurements were performed at baseline and after cessation of RAP. LA-A after RAP significantly enlarged and LAA-E velocities were significantly reduced compared with baseline values. RAP produced a significant elevation of ANF in a right atrial and in peripheral samples compared with baseline values. The change in plasma ANF correlated well with changes in LAA-E, but the correlation with LA-A was not significant. Our findings support the hypothesis that structural remodeling caused by RAP as a model of atrial fibrillation is a stimulus for release of ANF in the atria. In seems that atrial size and impaired systolic appendage function play an important role in secretion of ANF.
Deskriptorji		CARDIAC PACING, ARTIFICIAL ATRIAL FIBRILLATION ATRIAL NATRIURETIC FACTOR ATRIAL FUNCTION, LEFT SYSTOLE ECHOCARDIOGRAPHY, TRANSESOPHAGEAL DISEASE MODELS, ANIMAL DOGS