Avtor/Urednik		Ihan, A
Naslov		Imunski mehanizmi nutritivne alergije
Prevedeni naslov		Immunological mechanisms of food allergy
Tip		članek
Vir		In: Gregorič A, editor. Nutritivna alergija. Farmakologija perinatalnega obdobja. Skrb za zdravje v prvem letu življenja. Zbornik predavanj 13. srečanje pediatrov v Mariboru z mednarodno udeležbo; 2003 apr 4-5; Maribor. Maribor: Splošna bolnišnica Maribor,
Leto izdaje		2003
Obseg		str. 13-7
Jezik		slo
Abstrakt		Food allergy is an adverse reaction to foods that is mediated immunologically. Clinical manifestations of food allergy include symptoms of the gastrointestinal, cutaneous and respiratory systems, as well as systemic anaphylaxis. Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors will help to initiate migration of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. The development of food - specific T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to food will lead to tolerance or hypersensitive reactions.
Deskriptorji		FOOD HYPERSENSITIVITY IMMUNITY, MUCOSAL CYTOKINES INFLAMMATION T-LYMPHOCYTES, HELPER-INDUCER IGA ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE INTERLEUKIN-2 TH1 CELLS TH2 CELLS INTERFERON TYPE II INTERLEUKIN-12 INTERLEUKIN-4 INTERLEUKIN-10 CHEMOKINES