Avtor/Urednik		Pavičić, Fadila; Vrbica, Žarko; Popović-Grle, Sanja
Naslov		Liječenje stabilne kronične opstruktivne plućne bolesti (KOPB)
Tip		članek
Vir		In: Krajnc I, Hojs R, Pahor A, et al, editors. Zbornik predavanj in praktikum 14. srečanje internistov in zdravnikov splošne medicine Iz prakse za prakso z mednarodno udeležbo; 2003 maj 16-17; Maribor. Maribor: Splošna bolnišnica Maribor,
Leto izdaje		2003
Obseg		str. 39-51
Jezik		cro
Abstrakt		Chronic obstructive pulmonary disease (COPD) is characterized by a stable state and acute worsening of the disease. The aims of efficacous treatment are prevention of the disease progression, reduction of health problems, enhancement of exercise capacity, improvement of a general health state, prevention and treatment of complications as well as exacerbations and reduction of mortality. Cessation of smoking can be the most efficient and cost-effective intervention to reduce the risk of appearing of COLD and to reduce the disease progression. In the treatment of stable COPD, a graded approach is recommended. According to symptoms and spirometric values COPD can be classified into four stages. In a stage "0" spirometry of lung function must be performed regulary. Bronchodilatators are considered to be the most important drugs used for controlling the symptoms of the disease. In the stage II, a short acting bronchodilatators are administered as needed. In the stage II, an application of one or more bronchodilatators are recommended, as well as rehabilitation and application of inhaled corticosteroids (ICS), if FEVl < 50%, and frequent exacerbations or proved efficacy of ICS. In chronic obstructive lung disease, ICS do not have so remarkable effect as they have in asthma. A fixed combination of ICS and long acting beta agonists (LABA) in COPD have synergistic effect. In the stage III, beside previously mentioned therapy, complications are treated. Antibiotics are not recommended except for infectious exacrebations and other bacterial infections. A systemic application of corticosteroids in a stable COPD is not indicated. In the patients who have PO2 of arterial blood < 55 mm Hg or have an expressed pulmonary hypertension, a long term application of O2 (>15 hours a day) is indicated. In the terminal phase of the disease a possibility of surgical treatment (reducing lung volume by surgical procedure or lung transplantation) should be considered.
Deskriptorji		LUNG DISEASES, OBSTRUCTIVE BRONCHODILATOR AGENTS ADRENERGIC BETA-AGONISTS ALBUTEROL 1-METHYL-3-ISOBUTYLXANTHINE CHOLINERGIC ANTAGONISTS GLUCOCORTICOIDS