Avtor/Urednik		Gubina, M; Novak-Jankovič, V
Naslov		Stress response to surgery
Tip		članek
Vir		In: Zabavnik Z, editor. Book of lectures of the 16th anaesthesia symposium Alpe Adria; 2003 May 9-11; Maribor. Maribor: Splošna bolnišnica,
Leto izdaje		2003
Obseg		str. 147-53
Jezik		eng
Abstrakt		Stress response comprises hormonal and metabolic changes, which follow body injury. fxcessive stress response during surgery is potentially harmful for the patient. Stress response is triggered in hypothalamus by cytokines, which are released at the site of injury, and afferent somatic and vegetative nerves, which mediate pain impulses from the site of tissue injury to the central nervous system. The result of activation of hypothalamo-pituitary-adrenal axis is secretion of stress hormones like cortisol, catecholamines and growth hormone. Stress hormones are responsible for changes in carbohydrate, fat and protein metabolism. The net effect of these hormones is increased catabolism of stored body energy and suppression of the immune system. Inhibition of excessive stress response is greatest with regional anaesthesia with local anaesthetics. Advantages of regional anaesthesia have a positive effect on surgical outcome in high-risk patients, but there are still no conclusive results about the effect on morbidity in low-risk patients.
Deskriptorji		ANESTHESIA, CONDUCTION ANESTHESIA, GENERAL STRESS