Avtor/Urednik		Štupnik, Š; Požar-Lukanovič, N; Novak-Jankovič, V
Naslov		Influence of clonidine on extubation time in laparoscopic cholecystectomies
Tip		članek
Vir		In: Zabavnik Z, editor. Book of lectures of the 16th anaesthesia symposium Alpe Adria; 2003 May 9-11; Maribor. Maribor: Splošna bolnišnica,
Leto izdaje		2003
Obseg		str. 155-60
Jezik		eng
Abstrakt		Introduction: Pneumoperitoneum during laparoscopic cholecystectomy induces major hemodynamic changes through mechanical and neurohumoral factors. Clonidine has been used to depress sympathetic response to surgery and to potentiate analgesia and sedation. The aim of our study was to investigate its effect on extubation time. Methods: In a double blind, randomized study, we observed 40 patients, ASA I-II, that was scheduled for elective laparoscopic cholecystectomy. They were randomly divided into two groups, clonidine (N=20) and control (N=20) group. The patients in clonidine group received 4 microg kg-1 clonidine in 100m1 saline infusion during 15 min before induction. The patients .in control group received only 100ml of saline infusion. Anaesthesia with isoflurane, fentanyl and vecuronium was used in both groups. Duration of the operation, the time at the last skin suture, the time at the extubation and ETlso and ErCO2 at that time points were noted. The time between the last skin suture and the extubation was defined as extubation time. All this values were compared between groups. 2-tailed Student T-test was used for statistical analysis. Results: Extubation time (min) was significantly prolonged in the clonidine group (11+-7) compared to the control group (5+-3),(p <0,001). ETlso (vol. %) at the end of operation was significantly higher in the control group (0,69+-0,16) compared to the clonidine group (0,48+-0,16), (p<0,001), while at the extubation there was no difference between the groups. Canclusions: Despite lower ETlso concentration at the end of operation clonidine prolonged extubation time in clonidine group, probably because of its effect on central nervous system. To prevent too long turn-over times beiween operations in a busy operation room, routine clonidine premedication for short procedures is not recommended. Still, it can be useful to blunt exaggerated hypertensive response in hypertonics.
Deskriptorji		CHOLECYSTECTOMY, LAPAROSCOPIC CLONIDINE ELECTROCARDIOGRAPHY