| Avtor/Urednik | Avšič-Županc, Tatjana; Petrovec, Miroslav | |
| Naslov | Hemoragična mrzlica z renalnim sindromom: biologija, epidemiologija in laboratorijska diagnostika | |
| Prevedeni naslov | Hemorrhagic fever with renal syndrome: biology, epidemiology and laboratory diagnostic | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 42, št. Suppl 1 | |
| Leto izdaje | 2003 | |
| Obseg | str. 147-55 | |
| Jezik | slo | |
| Abstrakt | Hantaviruses from the Hantavirus genus belong to the Bunyaviridae family of viruses and are important pathogens in humans. Evolutionarily, hantaviruses are closely related to various rodent species; which are their natural hosts. They cause two types of diseases: hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and hantaviruš pulmonary syndrome (HPS) in the Americas: HFRS is caused by the Haantaan (HTN), Dobrava (DOB), Seoul (SEO) and Puumala (PUU) viruses, which are carried by mice, rats and voles. HPS is caused by the Sin Nombre (SN) virus carried by rodent species in the Americas. HFRS is present in Slovenia and has been diagnosed for over 15 years. Epizootiologic research in Slovenia has revealed that HFRS is endemic in some geographic regions, where small mammals infected with hantaviruses have been found. Two hantaviruses have been identified as the cause of HFRS the Dobrava and Puumala viruses; this is reflected by two diseases of different severity, involving different antibody responses in humans. The clinical manifestations of hantavirus infections are sometimes hard to delineate from those caused by Leptospira or Rickettsia spp. and possible hantavirus infection needs to be confirmed by laboratory tests. | |
| Izvleček | Hantavirusi iz rodu Hantavirus in družine Bunyaviridae so virusi, ki so pomembni povzročitelji bolezni pri ljudeh. V okolju se ohranjajo v svojih naravnih gostiteljih in prenašalcih, malih sesalcih, s katerimi so genetsko in evolucijsko tesno povezani. Povzročajo dve značilni bolezni: hemoragično mrzlico z renalnim sindromom (HMRS) in hantavirusni pljučni sindrom (HPS). HMRS povzročajo virusi Hantaan (HTN), Dobrava (DOB), Seoul (SEO) in Puumala (PUU), ki jih prenašajo miši, podgane in gozdne voluharice. HPS, povzroča virus Sin Nombre (SN), ki ga prenašajo miši "Novega sveta". HMRS je razširjena v Aziji in Evropi, medtem ko se HPS pojavlja na vsej ameriški celini. HMRS poznamo tudi v Sloveniji. Epizootiološke raziskave so pokazale, da je HMRS omejena na endemična področja, kjer je okužba malih sesalcev s hantavirusi pogosta. V Sloveniji povzročata bolezen virus Dobrava in virus Puumala, kar se odraža z različnim kliničnim potekom bolezni (težka in blaga oblika bolezni) in različnim protitelesnim odgovorom pri bolnikih. Laboratorijska potrditev hantavirusne okužbe je potrebna, saj se okužbe z leptospirami in rikecijami kažejo s podobnimi kliničnimi znaki: | |
| Deskriptorji | HEMORRHAGIC FEVER WITH RENAL SYNDROME HANTAVIRUS |