Avtor/Urednik		Kornhauser-Cerar, Lilijana; Bregant, Lev; Šelb, Gyula
Naslov		HELLP-sindrom: težka oblika preeklampsije - analiza novorojenčkov, zdravljenih na Enoti za intenzivno nego in terapijo Porodnišnice Ljubljana v letih 1995-2000
Prevedeni naslov		HELLP syndrome: severest form of preeclamsia - analysis of newborns treated at the Neonatal intensive care in therapy unit, Division of perinatology Ljubljana, in the period 1995-2000
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 42, št. Suppl 3
Leto izdaje		2003
Obseg		str. 17-20
Jezik		slo
Abstrakt		HELLP syndrome is the severest form of preeclampsia in the mother, characterized by hemolysis, increased levels of liver enzymes and thrombocytopenia. The effects on the fetus/newborn are mainly due to premature separation of placenta, asphyxia or severe immaturity and associated complications. Intrauterine growth retardation is a frequent consequence. A retrospective analysis involved 43 newborns of 40 mothers who delivered in the period 1995-2000 in the Maternity Hospital Ljubljana. We analysed birth weight, gestational age, diseases in the neonatal period, need for intensive,care management and duration of hospital stay. The results are presented as frequency (%) or as means +- standard deviation. Statistical significance was set at p < 0.05. Most pathology found in newborns of mothers with HELLP syndrome resulted from their immaturity. We failed to find-the diagnosis specifically associated with maternal HELLP syndrome. In one third of newborns we found hyaline membrane disease. Signs of general bacterial infection were found in 20% of survived newborns. The incidence of intracranial hemorrhage was low-13,5%. Most newborns were treated at the Neonatal Intensive Care and Therapy Unit; the rates, methods and duration of intensive treatment are comparable to those reported in literature.
Izvleček		Sindrom HELLP je težka oblika preeklampsije pri nosečnici, ki ga označujejo hemoliza, zvečana vrednost jetrnih encimov in trombocitopenija. Vplivi na plod ali novorojenčka so večinoma posledice prezgodnjega luščenja posteljice, asfiksije ali težje nezrelosti in z njo povezanih zapletov, pogost je tudi zastoj plodove rasti. V retrospektivni analizi je bilo zajetih 43 otrok pri 40 materah, katere so rodile v obdobju med leti 1995-2000 v Porodnišnici Ljubljana. Pregledali smo podatke o porodni teži in gestacijski starosti rojenih otrok, boleznih v obdobju novorojenčka, potrebo po intenzivnih postopkih zdravljenja ter trajanje hospitalizacije. Podatki so predstavljeni kot frekvenca (%) oziroma srednja vrednost s standardno deviacijo; vrednost p manj kot 0,05 smo upoštevali kot statistično pomembno. Večina patologije, ki smo jo zabeležili pri novorojenčkih mater s HELLP sindromom, je posledica njihove nezrelosti. Diagnoze pri novorojenčku, ki bi jo lahko značilno povezali z materinim HELLP sindromom, nismo našli. Pri tretjini novorojenčkov smo ugotovili hialinsko-membransko bolezen pljuč. Znake splošne bakterijske okužbe, smo našli pri petini preživelih novorojenčkov Pogostnost možganske krvavitve je bila nizka. Večino otrok smo zdravili na Enoti za intenzivno nego in terapijo novorojenčkov - delež, načini in trajanje intenzivnega zdravljenja so primerljivi z objavami v literaturi.
Deskriptorji		HELLP SYNDROME INFANT, NEWBORN, DISEASES INTENSIVE CARE UNITS, NEONATAL INFANT, NEWBORN BIRTH WEIGHT GESTATIONAL AGE HYALINE MEMBRANE DISEASE