| Avtor/Urednik | Vesel, Samo; Logar, Dušan | |
| Naslov | Prizadetost srca pri plodovih nosečnic s protitelesi proti antigenom Ro/SSA in/ali La/SSB | |
| Prevedeni naslov | Heart involvement in fetuses of anti-Ro/SSA and/or anti-La/SSB positive mothers | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 42, št. Suppl 3 | |
| Leto izdaje | 2003 | |
| Obseg | str. 83-8 | |
| Jezik | slo | |
| Abstrakt | The most important manifestation of transplacentary transmitted autoimmune - mediated inflammation in fetuses of anti - Ro/SSA and/or anti - La/SSB positive mothers is a development of complete congenital heart block. Although prognosis for the majority of patients is favourable, almost one third of them expire in utero or in early neonatal period. It is possible to diagnose, and in some cases even to treat a disease in utero, so the effort should be made to recognize those patients as soon as possible. The main diagnostic tool is fetal echocardiography Protocols to follow - up patients with prenataly-established diagnosis of complete autoimmune heart block and women with increased risk to give a birth to a child with complete heart block, are described. | |
| Izvleček | Najpomembnejši zaplet avtoimunega vnetja, ki nastane pri plodovih mater s skozi posteljico prenesenimi protitelesi proti antigenom Ro/SSA in/ali La/SSB, je nastanek popolnega prirojenega srčnega bloka. Tretjina bolnikov umre že in utero ali v zgodnjem neonatalnem obdobju, pri ostalih pa je napoved dobra. Bolezen je mogoče ugotoviti, v nekaterih primerih pa tudi zdraviti, že pred otrokovim rojstvom, zato je treba nanjo misliti in jo pri nosečnicah z večjim tveganjem aktivno iskati. Razpoznavo bolezni in spremljanje bolnikove hemodinamike omogoča fetalna ehokardiografija. Opisana sta protokola spremljanja in zdravljenja za bolnike s prenatalno ugotovljenim avtoimunim popolnim srčnim blokom, kot tudi za nosečnice, pri katerih je zaradi prisotnosti protiteles Ro/SSA in/ali La/SSB tveganje za rojstvo otroka s popolnim prirojenim srčnim blokom večje. | |
| Deskriptorji | LUPUS ERYTHEMATOSUS, SYSTEMIC HEART DEFECTS, CONGENITAL FETAL HEART HEART BLOCK PRENATAL DIAGNOSIS INFANT, NEWBORN |