Avtor/Urednik     Vrečer, Mateja
Naslov     Uporaba statinov v primarni in sekundarni preventivi koronarne bolezni srca in možganske kapi
Prevedeni naslov     Use of statins in primary and secondary prevention of coronary heart disease and stroke
Tip     članek
Vir     Farm Vestn
Vol. in št.     Letnik 54, št. Poseb št
Leto izdaje     2003
Obseg     str. 123-7
Jezik     slo
Abstrakt     Cardiovascular disease, including coronary heart disease, is the leading cause of death in the developed countries. By preventive actions against the majority of risk factors, the progression of the disease can be slowed down, at lest to some extent. If the usual measures such as healthy nutrition, giving up smoking, reduction of body weight, regular exercise atid reduction of stress proved to be ineffective, the accompanying diseases (hypertension, hyperlipidemia) should be medicated. Clinical studies proved statins to effectively reduce the level of LDL cholesterol, total cholesterol, triglycerides and increase HDL cholesterol levels. Statistics proved statins to significantly reduce relative risk of coronary events during the primary and secondary prevention. They also reduce the risk of cardiovascular death during this period. The effectiveness of statins is in correlation with the risk - the greater the risk of coronary heart disease and cardiovascular disease, the greater the potential reduction of their occurrence. Treatment with statins in primary prevention of stroke is statistical insignificant. During the secondary prevention statins statistical significantly reduce relative risk of non-fatal and total stroke occurrence.
Izvleček     Kardiovaskularne bolezni, vključno s koronarno boleznijo srca so glavni vzrok smrti v razvitih državah. S preventivnim delovanjem na dejavnike tveganja lahko preprečimo razvoj bolezni in vsaj do določene stopnje zavremo njeno napredovanje. Poleg splošnih ukrepov (zdrava prehrana, prenehanje kajenja, zmanjšanje prevelike telesne teže, redna telesna vadba, zmanjševanje stresa) in v primerih ko le-ti sami niso uspešni je potrebno bolezni (hipertenzija, hiperlipidemija) zdraviti tudi z zdravili. S kliničnimi študijami so dokazali, da statini učinkovito znižajo nivo LDL holesterola, skupnega holesterola, trigliceridov in povišajo nivo HDL holesterola. Statini statistično značilno zmanjšajo relativno tveganje pojava koronarnih dogodkov v primarni in v sekundarni preventivi. Prav tako zmanjšajo tveganje kardiovaskularne umrljivosti v primarni in v sekundarni preventivi. Stopnja učinkovitosti statinov je premosorazmerna s tveganjem - večje je tveganje za pojav koronarne bolezni srca in kardiovaskularne bolezni, večje je zmanjšanje relativnega tveganja za njun pojav. Učinek zdravljenja s statini v primarni preventivi možganske kapi je statistično neznačilen medtem ko v sekundarni preventivi zdravljenje s statini statistično značilno zmanjša število nesmrtnih in skupnih možganskih kapi.
Deskriptorji     CORONARY DISEASE
CEREBRAL INFARCTION
ANTILIPEMIC AGENTS