Avtor/Urednik		Dugonik, A; Belič, M; Miljković, J
Naslov		Eosinophilic fasciitis
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 12, št. 2
Leto izdaje		2003
Obseg		str. 72-5
Jezik		eng
Abstrakt		A 58-year-old woman was evaluated for disseminated scleroderma-like skin lesion which started on lateral aspects of the upper extremities and progressed rapidly, involving trunk and lower extremities. They first skin lesions appeared one month after she had started simvastatin therapy for hypercholesterolemia. Clinical and histopathological findings čorresponded to the diagnosis eosinophilic fasciitis. Methylprednisolone 60 mg per day was started; simvastin was discontinued. After two weeks of therapy the patient became afebrile, arthralgic pains and edema of legs subsided, and skin lesions softened. The percentage of eosinophils dropped to normal. The eosinophilic fasciitis was possibly induced by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, simvastatin, an association that has been previously described.
Deskriptorji		FASCIITIS EOSINOPHILIA HYDROXYMETHYLGLUTARYL COA REDUCTASES MIDDLE AGE