Avtor/Urednik		Jarc-Vidmar, Martina; Kraut, Aleksandra; Hawlina, Marko
Naslov		Fundus autofluorescence imaging in Best's vitelliform dystrophy
Tip		članek
Vir		Klin Monatsbl Augenheilkd
Vol. in št.		Letnik 220, št. 12
Leto izdaje		2003
Obseg		str. 861-7
Jezik		eng
Abstrakt		Background: It is well known that with age lipofuscin accumulates in the retinal pigment epithelium (RPE). In many inherited macular dystrophies such as Best's disease abnormally high levels of lipofuscin were found by histopathological studies. In recent years, it has become possible to detect and image fundus autofluorescence in the living eye as an indexof lipofuscin accumulation in the RPE. The aim of our study was to document the intrinsic fundus autofluorescence in patients with different stages of Best's disease and to correlate fundoscopic features with visual function in these patients. Methods: Images of fundus autofluorescence were obtained from 10 patients with Best's vitelliform dystrophy, using a Heidelberg Retina Angiograph (HRA). Argon laser light (488 nm) was used for illumination, and a wide-bandpass filter with acutoff of 500 nm was inserted in front of the detector to obtain the autofluorescence images. Images were compared withfundus appearance and fluorescein angiograms as well as with visual acuity, colour vision, visual fields andelectrophysiological recordings in these patients. Results: In initial stages of Best's disease, there were localised areas of hyperfluorescence centrally in the fovea, later being replaced by central hypofluorescence (atrophic) areas surrounded by hyperfluorescent rings. The evolution of autofluorescence pattern showed centrifugal spreading of retinal dysfunction from the centre towards periphery. Atrophic regions of the RPE were associated with low levels of background autofluorescence, lower visual acuity, abnormal colour vision (70% of patients), central scotomas (85% of patients) and poorer electrophysiological results (reduced PERG responses in 4% of patients with Best's disease). (Abstract truncated at 2000 characters).
Deskriptorji		MACULAR DEGENERATION LIPOFUSCIN FUNDUS OCULI VISUAL ACUITY FLUORESCEIN ANGIOGRAPHY MIDDLE AGE COLOR VISION DEFECTS VISUAL FIELDS ELECTRORETINOGRAPHY MICROSCOPY, CONFOCAL