Avtor/Urednik		Buturović-Ponikvar, Jadranka; Marin, Irena
Naslov		Razporeditev genotipov humanih virusov papiloma pri ženskah v Sloveniji
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 105
Jezik		slo, eng
Abstrakt		Infection with high-risk genotypes of human papillomavirus (HPV) plays the major aetiological role in the development of cervical cancer, which represents the second most common cancer in women worldwide as well as in Slovenia. Information on distribution of HPV genotypes in women in a given country is necessary for the selection of the appropriate screening test for detection of HPV infection as well as for the development of effective vaccines directed against HPV in the future. Therefore, the purpose of the present study was to examine the spectrurri of HPV genotypes in women in Slovenia. By restriction fragment lenght polymorphism (RFLP) 21 different HPV genotypes were identified in 191 women. In all women cervical smears were taken at a routine gynecologic examination. HPV16 was found to be the most prevalent HPV genotype in Slovenia (44,5%), followed by HPV31 in 11,5%, HPV58 in 11%, HPV33 in 6%, HPV53 in 5,2%, HPV18 in 3,7%, HPV6 in 3,2%, HPV56 in 3,2% and other HPV genotypes that accounted for less than 3%. In our study HPV16 was found to be the most prevalent among women with cervical cancer. This result is in line with the results obtained in other studies worldwide. However, the distribution of other HPV genotypes in women with cervical cancer in Slovenia was different from the distribution of HPV genotypes in other European countries. Slovenia is the only European country where HPV58 is the second most common HPV genotype in women with cervical cancer. (Abstract truncated at 2000 characters)
Deskriptorji		PAPILLOMAVIRUS, HUMAN GENOTYPE CERVIX NEOPLASMS CERVICAL INTRAEPITHELIAL NEOPLASIA VAGINAL SMEARS POLYMORPHISM, RESTRICTION FRAGMENT LENGTH SLOVENIA