| Author/Editor | Mijovski, Gordan | |
| Title | Molekularnogenetska preiskava možnih prekanceroz pri nastanku raka želodca | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2003 | |
| Volume | str. 72 | |
| Language | slo | |
| Abstract | The development of gastric cancer is a consequence of multistage process of genetic and epigenetic changes of oncogenes, tumor suppressor genes, mismatch repair genes, cell adhesion molecules' genes, telomeres and telomerase activity, and also genetic instability in general, which has been detected at several microsatellite loci. The specific combination of multiple alterations is different for the two histological types, which indicates that there are two different genetic pathways, for the well differentiated (intestinal) and poorly differentiated (diffuse) type gastric cancer. The alterations at the gastric mucosa appear at the beginning of both potential pathways and are therefore the subject of our study, which aims to contribute to the revealing of the insight of the complete process of carcinogenesis of the gastric cancer. Precancerous lesions that lead to development of gastric cancer and are also a subject of our research are the following: chronic atrophic gastritis, intestinal metaplasia and dysplasia, and peptic ulcer. As an additional risk factor we are also investigating the infection of the stomach with Helicobacter pylori. We have studied the differential expression of oncogenes in samples of precancerous and normal tissue of gastric mucosa, with the approach for simultaneous detection of difference in expression of several oncogenes. Our aim was to detect the possible existence of a pattern in the expression of the following seven oncogenes, and to check the possible role of Helicobacter pylori in the multistage process of carcinogenesis. (Abstract truncated at 2000 characters) | |
| Descriptors | STOMACH NEOPLASMS PRECANCEROUS CONDITIONS HELICOBACTER PYLORI ONCOGENES EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE FIBROBLASTS CYCLINS POLYMERASE CHAIN REACTION ELECTROPHORESIS, CAPILLARY |