Author/Editor		Čučnik, Saša; Božič, Borut
Title		Cerebrovascular manifestations in antiphospholipid syndrome
Type		članek
Source		Biochem Med
Vol. and No.		Letnik 11, št. 3-4
Publication year		2001
Volume		str. 93-6
Language		eng
Abstract		Antiphospholipid antibodies (alphaPL) are a diagnostic criterion for antiphospholipid syndrome, which is clinically characterized by venous or arterial thrombosis and recurrent spontaneous abortion. Attempts have also been made to explain various neurologic disorders such as stroke, migraine, epilepsy, dementia, cognitive dysfunction, depression, psychosis, chorea, etc., by the presence of aPL. However, not all these disorders could be explained by a single mechanism, as they belong to both uaseular and nonuascular neurologic diseases. Cerebral ischemia is the most common arterial thrombotic manifestation associated with the presence of aPL. Depression, psychosis and cognitive dysfunction in the presence of alphaPL can only in part be ascribed to cerebral ischemia, whereas in chorea and transverse myelitis direct aPL binding to cellular elements of the central nervous system appears to be the most likely mechanism involved. Considering possible explanations for neurologic and other clinical disorders, it should not 8e forgotten that aPL are a heterogeneous group of antibodies. In patients with neurologic disorders, diagnostic value of alphaPL can be increased by patient testing for antibodies against beta2 protein 1, prothrombin, C and S proteins, anexin, etc.
Descriptors		ANTIPHOSPHOLIPID SYNDROME CEREBROVASCULAR DISORDERS ANTIBODIES, ANTIPHOSPHOLIPID