Author/Editor		Tomšič, M; Vizjak, A; Plešivčnik-Novljan, M; Perković, T; Rozman, B
Title		Imunohistološke preiskave kože in malih žlez slinavk pri Sjoegrenovem sindromu
Translated title		Immunohistologic studies of skin and sublabial salivary glands in Sjoegren's syndrome
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 61, št. 1
Publication year		1992
Volume		str. 7-9
Language		slo
Abstract		Background: The authors describe their experiences with immunofluorescent examination of the skin and of the sublabial salivary glands in patients with the Sjögren's syndrome. Methods: Frozen slices of skin and sublabial salivary glands were incubated with antibodies against IgG, IgA, IgM, C3, Clq, C4 and fibrin/fibrinogen was marked with fluorescein isotiocianate. Results: Positive skin immunohistological findings were observed in 7 out of 21 patients (33 per cent) with primary Sjögren syndrome. Five cases showed IgM deposits on the dermo-epidermal border, in 2 cases vascular deposits were found and in another 2 nuclear IgG staining. In 11 patients out of 42 with sicca symptoms (26 per cent) IgA, IgG and IgM deposits were observed at the basal membrane of the glandular epithelium, while in one patient IgG positive nuclear immunofluorescence was found. Conclusions: IgM deposits on the dermo-epidermal border are not pathognomonic for patients with primary Sjögren's syndrome but they do have their own characteristics (generally they are fine granular and ribbon-like). Immunoglobulin deposits in the sublabial salivary glands in patients with primary Sjögren's syndrome is a concurrent phenomenon and of no diagnostic value.
Descriptors		SJOGREN'S SYNDROME SKIN SALIVARY GLANDS, MINOR IGA IGG IGM COMPLEMENT 3 COMPLEMENT 1Q COMPLEMENT 4 FIBRIN FIBRINOGEN FLUORESCENT ANTIBODY TECHNIQUE