Author/Editor		Serio, G; Gale, N; Pennella, A; Dalena, AM; Giardina, C; Valente, T; Lettini, T; Ricco, R; Resta, L
Title		La classificazione di Ljubljana delle lesioni iperplastiche dell' epitelio laringeo: valutazione morfometrica del pleomorfismo nucleare
Translated title		The Ljubljana classification of epithelial hyperplastic laryngeal lesions: a morphometric evaluation of nuclear pleomorphism
Type		članek
Source		Pathologica
Vol. and No.		Letnik 94
Publication year		2002
Volume		str. 290-8
Language		ita
Abstract		Epithelial hyperplastic laryngeal lesions (EHLL) are associated, with a varying degree of "epithelial risk" to develop invasive carcinoma. Several classifications have been proposed but none has received a total agreement. The 1999 Ljubljana classification distinguished four grades: simple, abnormal and atypical hyperplasia and in situ carcinoma (ISC). The first two grades are considered benign lesions; the ISC is the malignant lesion, while the atypical hyperplasia is considered a "risky lesion ". This is characterized by alterations of epithelial cells towards malignancy, but not to the extent to be found in carcinoma cells. Such characteristics refer to cytomorphological (e.g., nuclear hyperchromatism, nucleoli, increased nuclear/cytoplasmic ratio) and architectural (e.g., stratification, orientation, maturation) features. In the Ljubljana scheme, nuclear pleomorphism is one of the most important features. We wanted to improve the importance of nuclear pleomorphism in the basal cells layer in different classes of EHLL using morphometrical analysis. (Abstract truncated at 2000 characters)
Descriptors		LARYNGEAL NEOPLASMS CARCINOMA IN SITU CELL NUCLEUS LARYNX PRECANCEROUS CONDITIONS BIOPSY EPITHELIUM HYPERPLASIA SEVERITY OF ILLNESS INDEX