Author/Editor     Globočnik-Petrovič, M; Steblovnik, K; Peterlin, B; Petrovič, D
Title     The -429 T/C and -374 T/A gene polymorphisms of the receptor of advanced glycation end products gene are not risk factors for diabetic retinopathy in Caucasians with type 2 diabetes
Type     članek
Source     Klin Monatsbl Augenheilkd
Vol. and No.     Letnik 220
Publication year     2003
Volume     str. 873-6
Language     eng
Abstract     Objective: The aim of this study was to look for a relationship between the - 429 T/C and the - 374 T/A gene polymorphisms of the receptor of advanced glycation end products (RAGE) gene and the development of diabetic retinopathy in Caucasians with type 2 diabetes. Materials and methods: One hundred and sixteen subjects with type 2 diabetes and diabetic retinopathy were compared to 70 diabetic subjects without diabetic retinopathy. Additionally, 76 subjects with proliferative diabetic retinopathy (a subgroup of diabetic retinopathy) were compared to 70 diabetic subjects without diabetic retinopathy. Results: The -429 T/C and the - 374 TjA RAGE gene distributions in patients with diabetic retinopathy (-429T/C: CC 0.9%, TC 25.9%, TT 73.2%; - 374 T/A: AA 9.5%, TA 47.4%, TT 43.1%) were not significantly different from those of diabetic subjects without retinopathy (- 429 T/C: CC 0%, TC 25.7%, TT 74.3%; - 374 T/A: AA 15.7%, TA 42.9%, TT 41.4%). Moreover, the -429TJC and the -374T/A RAGE gene distributions in patients with proliferative diabetic retinopathy were not statistically significantly different from those in diabetic subjects without retinopathy. Conclusion: Our study failed to demonstrate an association between either - 429 T/C or - 374 T/A gene polymorphism of the RAGE gene and diabetic retinopathy in Caucasians with type 2 diabetes. Additionally, we failed to demonstrate an association between either - 429 TJC or - 374 T/A gene polymorphism of the RAGE gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
Descriptors     DIABETIC RETINOPATHY
POLYMORPHISM (GENETICS)
GLYCOSYLATION END PRODUCTS, ADVANCED
DIABETES MELLITUS, NON-INSULIN-DEPENDENT
HYPERTENSION
CHOLESTEROL
TRIGLYCERIDES
LIPOPROTEINS, HDL CHOLESTEROL
LIPOPROTEINS, LDL CHOLESTEROL
GENOTYPE
CROSS-SECTIONAL STUDIES