Author/Editor		Vizjak, Alenka; Jurčić, Vesna; Hvala, Asta; Ferluga, Dušan
Title		Tubulointerstitial immune deposits in renal diseases
Type		članek
Source		In: Vizjak A, Ferluga D, Bussolati G, editors. Update in pathology. Proceedings of the 19th European congress of pathology: nephropathology pre-congress meeting advances in nephrology, pulmonary pathology pre-congress meeting; 2003 Sep 6-11; Ljubljana. Ljubljana: Faculty of medicine,
Publication year		2003
Volume		str. 240-2
Language		eng
Abstract		The aim of this study was to evaluate in native kidney biopsies the prevalence and characteristics of extraglomerular tubulointerstitial immune deposits. All kidney samples were examined by light microscopy and immunofluorescence, and the majority also by electron microscopy. Granular tubulointerstitial immune deposits, suggesting an immune complex deposition pathogenetic mechanism, were found in lupus nephritis (57.4%), cryoglobulinemic glomerulonephritis, rare cases of ANCA positive vasculitis, Sjogren syndrome, membranous glomerulonephritis (9.6%), rare cases of other isolated glomerulonephritides, and in only one case of chronic tubulointerstitial nephritis. Linear immune deposits along the tubular basement membrane frequently appeared associated with linear glomerular immune deposits in Goodpasture syndrome (77.7%) and in individual cases (n=2) of drug-induced tubulointerstitial nephritis. We conclude that antibody mediated immune mechanisms are very rarely involved in the pathogenesis of tubulointerstitial nephritis, but are more frequently causally associated with tubulointerstitial lesions in various forms of glomerulonephritis, particularly those in systemic diseases. Renal tubulointerstitial immune deposits may be demonstrated in certain forms of glomerular disease, particularly glomerulonephritides in autoimmune systemic diseases, in which glomerular and tubulointerstitial lesions are mediated by the same pathogenetic mechanism (1,2). This can be either immune complex deposition or binding of autoantibodies to the antigens of the glomerular and tubular basement membrane (3,4). Tubulointerstitial immune complex deposition, associated with glomerular immune deposits, is a well known characteristic of glomerulonephritis in systemic lupus erythematosus (SLE) and cryoglobulinemic glomerulonephritis and has occasionally been described in patients with Sjogren syndrome (5). (Abstract truncated at 2000 characters).
Descriptors		NEPHRITIS, INTERSTITIAL IMMUNE COMPLEX DISEASES GLOMERULONEPHRITIS BIOPSY IGG IGA IGM