Author/Editor		Jerin, Aleš; Požar-Lukanovič, Neva; Sojar, Valentin; Stanisavljevič, Dragoje; Paver-Eržen, Vesna; Osredkar, Joško
Title		Balance of pr- and anti-inflammatory cytokines in liver surgery
Type		članek
Source		Clin Chem Lab Med
Vol. and No.		Letnik 41, št. 7
Publication year		2003
Volume		str. 899-903
Language		eng
Abstract		Inflammatory response in surgery is associated with the releass of cytokines. Many cytokines are produced by macrophages; therefore surgical injuries to the liver may have great infiuence on ths release of cytokines. ischemia creates tissue injury and may contribute to the cytokine releasa. A balanced ratio of pro- and antiinflammatory cytokines is important for appropriate immune response; excessive inflammation or hypo-responsiveness can lead to post-operative complications. To determine the magnituds of the cytokine response caused by liver surgery and to evaluate the balance of pro- and anti-inflammatory cytokines released during the operation, we measured levels of tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1beta, IL-6 and IL-10 in 19 patients undergoing liver resection. The results showed a continuous rise of IL-6 and a transient elevation of IL-10. Levels of TNFalpha remained low; IL-1beta was not detected at any sampling time. We conclude that liver surgery induces cytokine response characterized predominantly by an early appearance of IL-6 and IL-10, the elevation of IL-6 may be mainly caused by splanchnic ischemia. The IL-6/IL-10 ratio could possibly reflect the balance of pro- and anti-inflammatory cytokines in liver surgery better than the TNFalpha/IL-10 ratio, which can well represent inflammatory status in sepsis.
Descriptors		CYTOKINES LIVER NEOPLASMS INTERLEUKIN-1 INTERLEUKIN-6 INTERLEUKIN-10 ENZYME-LINKED IMMUNOSORBENT ASSAY PROSPECTIVE STUDIES HEPATECTOMY MACROPHAGES TUMOR NECROSIS FACTOR