Author/Editor		Kayser, Klaus; Kosjerina, Zdravko; Kasmierczak, Bernd; Hillmann, Christin; Vollmer, Ekkehard; Goldmann, Torsten; Kayser, Gian
Title		Squamous metaplasia and dysplasia - lesions associated to bronchial carcinomas?
Type		članek
Source		In: Vizjak A, Ferluga D, Bussolati G, editors. Update in pathology. Proceedings of the 19th European congress of pathology: nephropathology pre-congress meeting advances in nephrology, pulmonary pathology pre-congress meeting; 2003 Sep 6-11; Ljubljana. Ljubljana: Faculty of medicine,
Publication year		2003
Volume		str. 370-2
Language		eng
Abstract		To our understanding, the development of lung cancer is not a „sudden event". To the contrast, its manifestation lasts for years. Thus, the question of precursor stages such as squamous metaplasia and dysplasia arises. Material and methods: Our today's knowledge of phenotype, genotype, and cytogenetic morphology about alterations of bronchial mucosa in association with bronchial carcinomas is analyzed according to data of the literature. Of specific interest are morphologic and cytogenetic data in relation with lung lesions, to distance from tumor boundary, and the corresponding tumor cell type. Three own prospective studies (two about morphology, and a third about cytogenetic data) comprising a total of 51 cases with 17 detected lesions, 256 carcinomas with 51 detected lesions, and 55 carcinomas respectively are discussed in detail. For these studies bronchial biopsies were taken at distances 10, 20, 30, and 40 mm from tumor boundary, and analyzed by light microscopy (study I, study II) as well as by analyzing chromosomes of 10 metaphases (study III) respectively. Results: The WHO defines bronchial dysplasia into the three categories mild, moderate, severe, and into carcinoma in situ. The morphologic differentiation of dysplasia degrees is based upon cellular and nuclear features. These include nuclear and cellular size (distinguishing mild from moderate atypia), nucleoli mitoses, condensed nuclear chromatin (mild from severe atypia). In squamous dysplasia, often a deletion of histoblood group A antigen and a strong expression of Lewis Y Le(Y) antigen has been noted. These findings are in aggregation with reported alterations of histoblood group binding alterations in preneoplastic lesions of the lung. (Abstract truncated at 2000 characters).
Descriptors		LUNG NEOPLASMS METAPLASIA BRONCHIAL NEOPLASMS HYPERPLASIA CYTOGENETICS