Author/Editor		Drobnič, Matej
Title		Uspešnost zdravljenja hrustančnih lezij na femoralnih kondilih z uporabo gojenih avtolognih hondrocitov
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 83
Language		slo
Abstract		Focal chondral lesions are a common cause of pain and dysfunction of the knee joint. Due to a limited healing potential of articular cartilage they can progress into an early osteoarthritis. Autologous chondrocyte transplantation (ACT) is the most promising of several cartilage repair techniques that have been popularized in last ten years. Inspired by good results of Peterson et al. we introduced ACT to the University Medical Centre of Ljubljana, Slovenia in 1996. We have treated 75 patients so far. The purpose of present study was clinical, arthroscopical and histological analysis of the first 40 patients (41 knees) treated with ACT by the end of 2001. They all suffered from focal chondral lesions on femoral condyles, ICRS grade III to IV. We used standardized protocols of cartilage harvesting, cell cultivation, implantation of chondrocyte suspension under a periostal flap, and postoperative rehabilitation for all our patients. We introduced a modified lesion debridement technique (reversed osteal grafting - ROG) in 12 cases where the base of the chondral lesion was sclerotic. Eight patients recieved chondrocytes seeded on a fibrin-collagen type of scaffold next to the suspension. Ten patients required simultaneous anterior cruciate ligament reconstruction with the patellar tendon graft. The patients were divided into three groups: HONDRO (isolated lesions) - 18 patients, OCD (osteochondritis dissecans) - 12 patients (13 knees), and LCA (concomitant rupture of the anterior cruciate ligament) - 10 patients. One patient from OCD group was excluded from follow-up due to re-injury of the operated knee. Examination form and Tegner activity scale. Patients were evaluated on the day prior to implantation and re-evaluated at one, two, four, and six years postoperatively. (Abstract truncated at 2000 characters).
Descriptors		KNEE INJURIES CARTILAGE, ARTICULAR OSTEOCHONDRITIS DISSECANS ANTERIOR CRUCIATE LIGAMENT CELLS, CULTURED TENDON TRANSFER TREATMENT OUTCOME ARTHROSCOPY POSTOPERATIVE COMPLICATIONS