Author/Editor		Peč, M; Adamicova, K; Chribikova, I; Jautova, J; Peč, J
Title		Regression of dermal mast cell infiltrates in patients with cutaneous mastocytosis
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 12, št. 3
Publication year		2003
Volume		str. 89-93
Language		eng
Abstract		Background. Fourteen children with urticaria pigmentosa (UP) and two with disseminated cutaneous mastocytosis (DCM) were followed. Methods. Three skin biopsies were performed: the first one before the age of 2 years, the second one after 1-year treatment and the third 6 years after the second. Results. The repeated biopsy after the 1-year treatment resulted in a 20-60% regression of the mast cell infiltrates, while the third one disclosed a 70-90% reduction of these infiltrates. In UP patients the mast cell infiltrate changed from vessel unit type >55 micro m to <55 micro m. In both the DCM patients the mast cell infiltrate changed into the type >55 micro m. In the two nontreated UP patients the mast cell infiltrate type remained <55 micro m. Conclusion: The authors observed a spontaneous regression of the mast cell infiltrates in mastocytosis patients during adolescence; the treatment can however essentially influence their reduction.
Descriptors		URTICARIA PIGMENTOSA MAST CELLS CHILD BIOPSY