| Author/Editor | Praprotnik, D | |
| Title | Ekstrakapilarna kapsulna proliferacija pri sistemskem lupusu eritematozusu | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1991 | |
| Volume | str. 76 (95) | |
| Language | slo | |
| Abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease whose pathogenetic mechanisms are still not fully clarified. Besides the deposition of circulating immune complexes or their in situ formation, other immune mechanisms might also be important, particulary those which are directly targeted against one's own cells or those of cellular immunity. The pathogenetic mechanisms and development of extracapillary crescents are also not clarified. Extracapillary crescents (EC) can appear during the course of any type of glomerulonephritis (GN). The reports of other authors differ significantly as to the presence of EC and their various constituents, and even more as to their significance.Interstingly, the development of prognostically very unfavourable extracapillary GN (Ex-GN), characterized by an extracapillary proliferative response of at least 50 per cent of glomeruli, is rare in SLE. We still do not understand why crescents should appear at all. We were interested in the differences in different biopsies and, later, more particularly, in the differences in individual glomeruli in the same biopsy. We devided selected specimens firstly into two groups: those with more than 50 per cent of glomeruli with EC and those without EC, in an attempt to confirm and possibly gain further information on the pathogenesis of SLE glomerulonephritis. We also studied rebiopsies, when available, to determine the fate of the Malpighian corpuscles. In all, 29 biopsies an 9 rebeopsies were studied of patients with diffuse proliferative LGN, and their cellular components studied. Monoclonal or policlonal antibodies and a lectin were used to indentify the various cells and extra cellular matrix components. Light mikroscopy immunofluorescent and electron microscopy methods were also used. We found many statistically significant differences between the two groups.(trunc.) | |
| Descriptors | LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS NEPHRITIS IMMUNOHISTOCHEMISTRY BIOPSY FLUORESCENT ANTIBODY TECHNIQUE MICROSCOPY, ELECTRON GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE IMMUNOENZYME TECHNIQUES |