Author/Editor		Šikovec, A
Title		Vpliv etanola na celjenje eksperimentalne poškodbe kosti pri podgani
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1991
Volume		str. 75 (96)
Language		slo
Abstract		To find out wether drinking alcohol (Alcohol is used as a synonim for ethanol) after an experimental bone injury influences bone healing with rats, the author made an experimental bone injury in a group of thirty rats. the injury was made by drilling a hole with a dentist drill burr of the diameter of 1,1 mm into the parietal bone. The rats were divided into three groups differing from each other only by the kind of fluid they had drunk. Group I(13 rats) had drunk only tap water, group II(8 rats) had drunk 10 vol. per cent of ethanol diluted in tap water and group III(9 rats) had drunk 20 vol. per cent solution of ethanol. We established that the average ingestion of pure ethanol was 7,76 gr. per day per 1 kg of body weight (BW) in group II and 20,8 gr. per day per 1 kg of body weight in group III. The amount of ingested ethanol in group III exceeded the capacity of methabolic ethanol break down and therefore the blod ethanol levels were measured up to 1,68 gr./KG of body weight. The weight gain was the lowest in group II. The transaminases levels were significantly higher in groups II and III. The liver weight did not differ between the groups nor did the morphological appearance. Group II had elevated serum calcium level. In the same group the average magnesium level was the lowest. The rats were sacrificed 28 days after the injury had been made. The whole parietal bone including the bone wound area was taken out and stained with Alizarin S red for calcium on the surface of tne bone. The bone wound area was photographed gations will be necessary. under microscope with ten time magnification. The bone wound area wich was not coloured was in the reverse porportion to yhe newly formed bone. The surface area wich was not coloured was measured by picture digitalization and personal computer. The average portion of the wound hole not ossificated was 1430,6+-395,8 mm2 in group I, 1581,16+-719,56 mm2 in group II and 1678,3+-411,73 mm2 in group III.(trunc.)
Descriptors		SKULL FRACTURES WOUND HEALING ALCOHOL, ETHYL PARIETAL BONE RATS ANIMALS, LABORATORY CALCIUM MAGNESIUM PHOSPHORUS ASPARTATE AMINOTRANSFERASE ALANINE AMINOTRANSFERASE GAMMA-GLUTAMYLTRANSFERASE BIOMETRY