| Author/Editor | Zorec-Karlovšek, M | |
| Title | Forenzični pomen hemoglobina A1: posmrtna biokemijska diagnostika diabetesa mellitusa in diabetične kome | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1992 | |
| Volume | str. 154 | |
| Language | slo | |
| Abstract | Reliable posmortem diagnosis of diabetis mellitus and fatal diabetic coma is of great importance in forensic medicine. The main forensic viewpoints touch questions in connection with inappropriate medical treatment, withholding of medical assistance, suspicion of poisoning and finaly also the influence of external violence as a cause of death when injuries are at issue because of a fall in precomatose stages. To these are attached additional questions of evaluation of the state of health and the abilities of drivers-diabetics for their safe joining into traffic. The postmortem diagnosis of diabetes mellitus or diabetic coma must always be a syntesis of several possible data: anamnesis, clinical diagnosis, pathomorphological findings and the results of posmortem chemistry, which play an important role because they can decisively complement the often deficient or insufficient and non-specific data available. In this study in which links were sought between postmortally defined biochemical values, diabetes mellitus and the cause of death of patients suffering from diabetes mellitus, 231 cases were included, 66 of which were diabetics and 165 others consisted a control group. The following postmortem smples from the femoral vein samples of cerebrospinal fluid, vitreous humor and urine. In these body fluids we measured several biochemical values, among which glycosylated hemoglobin (HbA1), glucose, the sum of glucose and lactate, ketonic bodies - free acetone and total carbon dioxyde are important for the diaghemoglobin are among the important indicators of vital glycemia. nosis of diabetes mellitus and diabetic coma. Glycosylated hemoglobin remains stable after death, even after storage of the samples (at least 14 days) at the temperature of +4 degrees celsious. It therefore offers data about antemortem metabolic state of patients suffering from diabetes mellitus.(trunc.) | |
| Descriptors | FORENSIC MEDICINE DIABETES MELLITUS DIABETIC COMA HEMOGLOBIN A, GLYCOSYLATED AUTOPSY AGE FACTORS BODY FLUIDS SPECTROPHOTOMETRY CHROMATOGRAPHY, HIGH PRESSURE LIQUID GLUCOSE LACTATES KETONE BODIES UREA CREATININE ELECTROLYTES |