| Author/Editor | Kocijančič, M | |
| Title | Vpliv 13-CIS-retinoične kisline na skelet | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1992 | |
| Volume | str. 95 (140) | |
| Language | slo | |
| Abstract | One of the skeletal abnormalities reported in patients on longterm treatment with 13-cis-retinoic acid is reduction of bone density. From results of in vitro experiments it is presumed that 13-cis-retinoic acid enhances resorption of bone. The author used modern biochemical and morphological methods in order to evalue possible clinically important changes of bone density through six-month treatment with low doses of 13-cis-retinoic acid. A clinically important influence defined was one which could in the period of six months stop the increase of bone density which normally increases from 0.5 to 7.0 per cent every year from puberty until late twenties. Depending on body weight and the severity of acne patients started the therapy with 0.5 to 1.0 mg/kg/day. the dose was gradually reduced depending on side effects and reduction of acne lesions. This treatment lasted six months. Before and after the treatment the patients were examined by dual photon densitometry of the lumbal spine. A rentgenological examination of lumbosacral spine and some parts of appendicular skeleton was made to detect possible bone changes that could influence the results of dual photon densitometry and followed the skeleton changes reported during 13-cis-retinoic acid treatment. Biochemical markers of bone turnover in the serum and urine which were determined before and at the end of the treatment were: vitamin D3, parathormone, osteocalcin, alkaline phosphatase in the serum; calcium/creatinine, hydroxyproline/creatinine in the urine. The average increase in bone density was 3.0 per cent (95 per cent CI 0.013-0.0480). Bone density increased in 13 out of 15 patients. Both patients without bone density increase were older than 18. Five out of seven patients yunger than 18 showed an accelerated ossification process. The changes of biochemical markers showed slowing of bone turnover in this age group.(trunc.) | |
| Descriptors | ACNE TRETINOIN LUMBAR VERTEBRAE BONE DENSITY ABSORPTIOMETRY, PHOTON BODY WEIGHT BODY HEIGHT ARM SPINE KNEE CALCIUM ALKALINE PHOSPHATASE CHOLECALCIFEROLS PARATHYROID HORMONES OSTEOCALCIN HYDROXYPROLINE |