Author/Editor		Petrovič, Daniel; Bregar, Dejan; Gužič-Salobir, Barbara; Škof, Erik; Špan, Matjaž; Terzić, Rifet; Globočnik-Petrovič, Mojca; Keber, Irena; Letonja, Mitja; Zorc, Marjeta; Podbregar, M; Peterlin, Borut
Title		Sex difference in the effect of ACE-DD genotype on the risk of premature myocardial infarction
Type		članek
Source		Angiology
Vol. and No.		Letnik 55, št. 2
Publication year		2004
Volume		str. 155-8
Language		eng
Abstract		In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI), I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.
Descriptors		MYOCARDIAL INFARCTION PEPTIDYL-DIPEPTIDASE A GENOTYPE POLYMORPHISM (GENETICS) CHOLESTEROL LIPOPROTEINS, HDL LIPOPROTEINS, LDL TRIGLYCERIDES RISK FACTORS DIABETES MELLITUS SMOKING HYPERTENSION BODY WEIGHT BODY HEIGHT SEX FACTORS ODDS RATIO