Author/Editor		Tul-Mandić, Nataša
Title		Presejalni test v prvi tretjini nosečnosti za kromosomopatije ploda in porodniške zaplete
Translated title		The first trimester screening test for fetal chromosomopathies and pregnancy complications
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 92
Language		slo
Abstract		A. Screening tests for detection of chromosomal abnormalities in the first trimester of pregnancy are becoming part of prenatal care. Additionally to the calculation of the fetal risk based on maternal age and fetal nuchal translucency (NT), biochemical markers, especially free beta human chorionic gonadotropin (fbetahCG) and pregnancy associated plasma protein A (PAPP-A) have proved to be rather promising. We aimed at making a screening test for detection of mothers carrying fetuses affected with chromosomal abnormalities. The test was based on maternal age, and serum levels of fbetahCG and PAPP-A, fetal NT measured between the 10th and 14th gestational week. B. Our second aim was to find whether maternal serum levels of fbetahCG, PAPP-A and inhibin A between the 10th and 14th gestationa) week were useful in the detection of mothers to experience obstetric complications. C. The third aim was to find whether the screening tests based on the levels of fbetahCG, PAPP-A and the NT measurements were appropriate for the women conceiving by assisted reproduction, as the second trimester triple test yielded a higher percentage of false positive results (FPR) in these women. Methods A. In a retrospective study we enrolled the mothers who came for an ultrasound examination at 10 to 14 gestational week: 210 had fetuses with trisomy 21, 50 fetuses with trisomy 18, 59 fetuses with abnormal sex chromosomes, and 947 mothers had normal fetuses. In fetuses the crown-to-rump length and NT were measured; in mothers serum levels of fbetahCG and PAPP-A were determined. We calculated medians for fbetahCG and PAPP-A for each day between the 1 Oth and 14th gestational week, and multiples of the median (MoM) for all mothers. We compared the values of fbetahCG, PAPP-a and NT between cases with trisomy 21, trisomy 18 or sex chromosome abnormalities and cases with chromosomally normal fetuses. (Abstract truncated at 2000 characters).
Descriptors		PREGNANCY TRIMESTER, FIRST PRENATAL DIAGNOSIS CHROMOSOME ABNORMALITIES ULTRASONOGRAPHY, PRENATAL GONADOTROPINS, CHORIONIC PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN RETROSPECTIVE STUDIES MASS SCREENING PREGNANCY DOWN SYNDROME TRISOMY CHROMOSOMES, HUMAN, PAIR 18 SEX CHROMOSOME ABNORMALITIES EMBRYO TRANSFER FERTILIZATION IN VITRO PREGNANCY COMPLICATIONS MATERNAL AGE DIABETES MELLITUS INHIBIN BIRTH WEIGHT OVULATION INDUCTION HYPERTENSION LABOR, PREMATURE