Author/Editor		Eržen, Barbara
Title		Endotelijska disfunkcija pri mladih moških po prebolelem srčnem infarktu
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 60
Language		slo
Abstract		Background: Endothelial dysfunction is the primary functional alteration of the arterial wall in patients with established classical risk factors for development of atherosclerosis (hypercholesterolemia, arterial hypertension, diabetes, smoking, obesity). Therefore it is assumed that endothelial dysfunction is the prerequisite for development of atherosclerosis, although the claim has never been sufficiently proved. At the same time heart attack occurs frequently in patients without clearly expressed classical risk factors. It has not yet been established whether such patients also have endothelial dysfunction, nor has it been determined how the latter might differ from that in the patients exhibiting classical risk factors. With patients who suffer heart attack yet exhibit no classical risk factors, the atherosclerosis is caused by other, the so-called non-classical risk factors. One of the recently most intensively studied factors is the altered (accelerated) inflammatory response. The occurrence, effect and diagnosing of the latter have not yet been sufficiently studied in patients with established atherosclerosis Aim of Research: The aim of our research was to establish whether endothelial dysfunction could be traced in young men who have suffered heart attack despite low coronary risk before the heart attack (i.e. lack of or weak classical risk-factors). We have compared it with the level of endothelial dysfunction in young patients with high coronary risk according to the presence of classical risk factors at the time of the heart attack (i.e. established classical risk factors). Our aim was to determine whether patients with high and low coronary risk, according to the presence of classical risk factors at the time of the heart attack, differ according to the level of blood inflammation markers during the stable period of the illness. (Abstract truncated at 2000 characters).
Descriptors		MYOCARDIAL INFARCTION ENDOTHELIUM, VASCULAR ATHEROSCLEROSIS INFLAMMATION MEDIATORS BRACHIAL ARTERY ADULT NITROGLYCERIN VASODILATION INTERLEUKIN-6 TUMOR NECROSIS FACTOR INTERCELLULAR ADHESION MOLECULE-1 VASCULAR CELL ADHESION MOLECULE-1 SELECTINS