Author/Editor		Varl, Janez
Title		Učinki ertitropoetinov EPO alfa in EPO omega pri bolnikih s kronično ledvično odpovedjo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 49
Language		slo
Abstract		The objective of the study was to evaluate and compare the safety and effectivenes of epoetin omega (produced in BHK cells) and epoetin alfa (produced in CHO cells) in sustaining the correction of anemia in maintenance hemodialysis patients. The study, a prospective and controlled crossover, was completed in 38 stable patients treated with both epoetins for 24 weeks. Group A (17 patients) started with epoetin omega and was switched to epoetin alfa after 24 weeks. Group B (21 patients) started with epoetin alfa and was switched to epoetin omega after 24 weeks for the next 28 weeks. Both epoetins were administered subcutaneously after each dialysis with the aim of maintaining a target hemoglobin level between 10 and 12 g/dl and hematocrit 30 to 35 %. Iron was supplemented intravenously as ferric saccharate. In group A, the mean weekly dose of epoetin omega /kg BW was 74 +- 55 U, and the mean weekly dose of epoetin alfa /kg BW was 95 +- 61 U. The difference assessed by the area under the dose curve (AUC) was significant (p = 0.039). In group B, the mean weekly dose of epoetin alfa / kg BW was 79 +- 45 U, and the mean weekly dose of epoetin omega / kg BW was 61 ` 30 U. The difference assessed by AUC dose was significant (p = 0.003). The average of all mean values of hemoglobin during treatment with epoetin omega was 11.4 +- 0.7 g/dl (hematocrit 34 +- 2%), and during treatment with epoetin alfa 11.3 +- 0.7 g/dl (hematocrit 33 +- 2%) (NS). The quotients between mean biweekly doses of epoetin omega per kg BW and hemoglobin were lover than during the epoetin alfa treatment period (p = 0.002). An integrated comparison of administered doses (area under the doses curve, AUC doses) of epoetin omega and alfa showed that a lower quantity of epoetin omega was given (p = 0.000). A median AUC dose for epoetin omega was 1481 and for epoetin alfa 1667 U/kgBW/24 weeks. (Abstract truncated at 2000 characters).
Descriptors		KIDNEY FAILURE, CHRONIC ERYTHROPOIETIN, RECOMBINANT HEMODIALYSIS ANEMIA HEMOGLOBINS HEMATOCRIT