| Author/Editor | Kansky, Andrej | |
| Title | Pomen okužbe s humanimi virusi papiloma v etiopatogenezi epitelijskih novotvorb ustne votline | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2003 | |
| Volume | str. 97 | |
| Language | slo | |
| Abstract | The human papillomaviruses (HPV) are small DNA viruses that belong to the family Papovaviridae. Infection with certain HPV genotypes are intimately linked with squamous epithelial cell benign and malignant lesions of the the anogenital region. Recent evidence suggests that HPV infection can contribute etiologically to some tumors in the oral cavity. However, the understanding of etiological role of HPV in oral carcinogenesis is hampered by the fact that there is a marked variation in the HPV DNA prevalence rate in tissue specimens of oral squamous cell carcinima and oropharingeal squamous cellcarcinoma (OSCC), varying from 0% to 100% The aim of our study was to elucidate further the putative etiologic role of HPV in oral malignant and benign tumors. Using four different polymerase chain reaction (PCR) protocols the presence of HPV DNA was investigated in tissue specimens obtained from three groups of patients, patients with oral . squamous cell carcinima and oropharingeal squamous cell carcinoma (OSCC), in patients with benign tumors of oral cavity and oropharynx (BOC) and in a control group of histologically normal oral and oropharyngeal mucosa tissue specimens (NOM), that were obtained from the individuals who matched the subjects with neoplasms in age, gender, localization of obtained tissue specimens and drinking and smoking habits. All together 273 tissue specimens were tested with four different PCR protocols: 104 OSCC, 49 BOC and 120 NOM. According to the available literature data, our investigation is the first study in which HPV-DNA prevalence was comparatively studied in tissue specimens of both oral squamous cell carcinoma patients and matching control subjects. HPV-DNA was detected in 10 of 104 (9,6%) tissue specimens of OSCC. HPV-DNA was detected in 4 of 76 (5,2%) tissue specimens from oral squamous cefl carcinomas and in 6 of 28 (21,4%) oropharyngeal squamous cell carcinomas (p=0.013). (Abstract truncated at 2000 characters). | |
| Descriptors | MOUTH NEOPLASMS PAPILLOMAVIRUS, HUMAN CARCINOMA, SQUAMOUS CELL OROPHARYNGEAL NEOPLASMS POLYMERASE CHAIN REACTION BASE SEQUENCE GENOTYPE |