Author/Editor		Petrovič, Danijel; Peterlin, Borut
Title		Pharmacogenomic considerations of the insertion/deletion gene polymorphism of the angiotensin I-converting enzyme and coronary artery disease
Type		članek
Source		Curr Vasc Pharmacol
Vol. and No.		Letnik 2, št. 3
Publication year		2004
Volume		str. 271-9
Language		eng
Abstract		Gene polymorphisms of components of the renin-angiotensin system angiotensinogen, angiotensin I-converting enzyme (ACE) and angiotensin II type 1 receptor (AT-1), have been considered to contribute to inherited predisposition towards coronary artery disease (CAD). The best analysed is the insertion/deletion (I/D) gene polymorphism of the ACE gene. Several studies suggest that the ACE D allele is associated with the occurrence of CAD and myocardial infarction. Moreover, the I/D polymorphism of the ACE gene has been thought to be related to diverse responses to drugs. Modern gene technologies may therefore provide the information, which may help to identify disease-associated genes and determine the responsiveness to a given drug.
Descriptors		CORONARY DISEASE PEPTIDYL-DIPEPTIDASE A RECEPTORS, ANGIOTENSIN GENE DELETION POLYMORPHISM (GENETICS) RENIN-ANGIOTENSIN SYSTEM PHENOTYPE ATHEROSCLEROSIS HYPERLIPIDEMIA HYPERTENSION