Author/Editor		Pavčnik-Arnol, Maja
Title		Pomen beljakovine, ki veže lipopolisaharid, prokalcitonina in interlevkina 6 v zgodnji diagnostiki hude okužbe kritično bolnih novorojenčkov in otrok
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 74
Language		slo
Abstract		Objective: Severe infection is a major cause of morbidity and mortality in critically ill neonates and children in intensive care units. Early detection of severe infection is difficult because clinical and laboratory signs are non-specific, and microbiological tests are relatively slow and have low sensitivity. As a consequence, antibiotics are overused in critically ill children and neonates. The objective of this study was to evaluate whether a new marker of severe infection, lipopolysaccharide binding protein (LBP), has better diagnostic accuracy for severe infection in critically ill neonates and children than routinely used laboratory tests: white blood cell count, serum C-reactive protein (CRP), interleukin 6 (IL-6) and procalcitonin (PCT) concentration. We also wanted to find out whether sequential determination up to 48 hours after suspicion of infection improves the diagnostic value of LBP. Patients and methods: Sixty critically ill neonates and children who had clinical and/or laboratory signs of severe infection on admission to or later during stay in multidisciplinary pediatric intensive care unit (PICU) were included into the study. Patients were classified into 2 groups. Group 1: critically ill neonates and children with clinical and laboratory signs of severe infection that received full parenteral antibiotic therapy (n = 33; sepsis 20, pneumonia 13; clinical sepsis in 8 patients, in 20 patients infection was microbiologically confirmed: Pseudomonas aeruginosa 2, Escherichia coli 2, Enterobacter aerogenes 1, Streptococcus agalactiae 6, Streptococcus pneumoniae 5, Staphylococcus aureus 3, coagulase negative staphylococci 1). (Abstract truncated at 2000 characters).
Descriptors		CRITICAL ILLNESS SEPSIS CALCITONIN LIPOPOLYSACCHARIDES PROTEIN BINDING INFANT, NEWBORN CHILD INTERLEUKIN-6 C-REACTIVE PROTEIN LEUKOCYTE COUNT ROC CURVE IMMUNOCHEMISTRY SENSITIVITY AND SPECIFICITY PLATELET COUNT