| Author/Editor | Žitnik, Simona Eva | |
| Title | Zdravljenje juvenilnega idiopatskega artritisa | |
| Translated title | Treatment of juvenile idiopathic arthritis | |
| Type | članek | |
| Source | Slov Pediatr | |
| Vol. and No. | Letnik 10, št. 2 | |
| Publication year | 2003 | |
| Volume | str. 106-12 | |
| Language | slo | |
| Abstract | Juvenile idiopathic arthritis (JIA) is the most common childhood chronic systemic autoimmune inflammatory disease. Better classification criteria and advances in knowledge of the aetiopathogenesis and physiology of the disease open up new possibilities for the treatment of JIA. Early diagnosis and correct, aggressive treatment of patients with bad prognostic indicators improve both the patient's quality of life and the final disease outcome. Apart from nonsteroidal anti-inflammatory drugs, methotrexate remains the mainstay in the treatment of JIA. Despite this, one third of patients do not respond favourably to treatment with methotrexate. For these patients, new possibilities for treatment with so-called bio drugs, such as tumour necrotizing factor alpha blockers are opening up. | |
| Summary | Juvenilni idiopatski artritis (JIA) je najpogostejša kronična avtoimuna sistemska bolezen v otroškem obdobju. Izpopolnjena klasifikacijska merila ter večje znanje o etiopatogenezi in fiziologiji bolezni odpirajo nove možnosti v zdravljenju JIA. Pravočasna postavitev diagnoze ter pravilno in agresivno zdravljenje bolnikov s slabimi prognostičnimi kazalci izboljšujejo kvaliteto življenja bolnikov ter končni izid bolezni. Poleg nesteroidnih antirevmatikov je metotreksat najpogosteje uporabljeno temeljno zdravilo pri zdravljenju JIA. Kljub temu ena tretjina bolnikov ne odgovori ustrezno na zdravljenje z metotreksatom. Za te bolnike se odpirajo nove možnosti zdravljenja s t. i. biološkimi zdravili, kot so npr. zaviralci faktorja alfa tumorske nekroze (TNFalfa). | |
| Descriptors | ARTHRITIS, JUVENILE RHEUMATOID ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL CYCLOOXYGENASE INHIBITORS IBUPROFEN NAPROXEN CHILD METHOTREXATE SULFASALAZINE ANTI-INFLAMMATORY AGENTS, STEROIDAL CYCLOSPORINS |