Author/Editor		Steblovnik, Lili
Title		Nuhalna svetlina ploda, fbeta-hCG in PAPP-A kot presejalni test v prvem trimesečju nosečnosti za odkrivanje nepravilnosti ploda
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 47
Language		slo
Abstract		Background. There are several methods of antenatal screening for aneuploidy, mostly Down's syndrome (DS). In Slovenia we identify women at increased risk of DS on the basis of maternal age or by maternal age and fetal nuchal translucency (NT) measurement between 10 and 13 weeks of gestation. In published studies the screening test using the combination of maternal age, maternal serum free beta human chorionic gonadothropin (fbeta-hCG), pregnancy-associated plasma protein A (PAPP-A) and NT has proved to be more effective than both tests currently in use in Slovenia. However, the fmdings of published studies about the influence of maternal weight, smoking habits, parity, gravidity and fetal gender on the markers are controversial. To the knowledge of the author, no studies have been published about the differences in medians between healthy pregnant women and those with hypertension or chronic renal disease. The aim of this study was to evaluate the efficiency of screening using a combination of maternal age, fbeta-hCG, PAPP-A and NT for calculating the risk for DS in the first trimester of pregnancy in the women from Slovenia. Besides, we wanted to study the influence of maternal weight, smoking habits, parity, gravidity and fetal gender on the markers, and fmd possible differences between healthy pregnant women and those with hypertension or chronic renal disease. Methods. We included 1264 women with singleton pregnancy in this observational study. NT was measured between 10 and 13 6/7 weeks; at the same time fbeta-hCG and PAPP-A were measured in blood samples. From chromosomally normal pregnancies we calculated nonnal medians for pregnant women from Slovenia. The risks of DS were calculated using the published methods. At risk cut-off 1 in 300 the screening test was considered positive. We compared NS, fbeta-hCG and PAPP-A between healthy pregnant women and those with hypertension or chronic renal disease. (Abstract truncated at 2000 characters).
Descriptors		PRENATAL DIAGNOSIS PREGNANCY TRIMESTER, FIRST DOWN SYNDROME CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN PREGNANCY-ASSOCIATED ALPHA-PLASMA PROTEIN PREGNANCY MASS SCREENING MATERNAL AGE GESTATIONAL AGE BODY WEIGHT SMOKING KARYOTYPING HYPERTENSION KIDNEY DISEASES ULTRASONOGRAPHY, PRENATAL MULTIVARIATE ANALYSIS