Author/Editor		Petelin, M; Pavlica, Z; Batista, Urška; Štiblar-Martinčič, Draga; Skalerič, U
Title		Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs
Type		članek
Source		Acta Vet Hung
Vol. and No.		Letnik 52, št. 1
Publication year		2004
Volume		str. 33-46
Language		eng
Abstract		In the present study the effects of different commercially available periodontal dressings (Peripac, Barricaid, Fittydent, Reso-Pack and Myzotect-tincture) on fibroblast (V-79-379A) proliferation and survival were tested in vitro. Barricaid, Fittydent and Reso-Pack periodontal dressings have only small inhibitory effects on cell proliferation (83.3 +- 9%, 71.6 +- 8.7% and 87.3 +- 4.5% of control after 48 h, respectively) in comparison with the great inhibitory effect of Myzotecttincture (2.9 +- 0.1%) and Peripac (33.7 +- I 1.4%) (p < 0.001). Barricaid was the only dressing where 41% of cells survived after exposure, while the other four dressings killed all the cells in 6 days. In addition, the healing of artificially created gingival wounds covered by Barricaid and Reso-Pack was followed for 7 days in 12 Beagle dogs. Histological evaluation of gingival tissue demonstrated that wounds covered by Reso-Pack showed the best epithelisation and vascularity and the least inflammatory reaction in first 4 days. Later the observed parameters were similar with those of wounds covered by Barricaid or without pack. The present results indicate that Peripac periodontal dressing and Myzotect-tincture showed the highest cytotoxicity to fibroblasts in vitro. From the histological observations in Beagle dogs Reso-Pack has been found to be the most suitable dressing, followed by Barricaid.
Descriptors		GINGIVECTOMY WOUND HEALING PERIODONTAL DRESSINGS FIBROBLASTS CELL SURVIVAL DOGS CELL DIVISION GINGIVA