Author/Editor		Kocijančič, B
Title		Vpliv refluksa želodčnega soka na varice požiralnika
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1992
Volume		str. 88
Language		slo
Abstract		reflux with 24-hour pH-metry of 30 patients with liver cirrhosis and portal hypertension, who had bled from esophageal or gastric varices and were treated at the University Department of Gastroenterology in Ljubljana Medical Center. Esophageal varices of those patients have been treated with three to nine sessions of sclerotherapy with other necessary therapy, including preventive therapy with prupranolol. These patients did not have symptoms or clinical signs of gastroesophageal reflux. The author confirmed the presence of gastroesophageal reflux in 20 patients. These results were compared to the results of 24-hour pH-metry in 30 patients , of the same age and sex, with clinical signs of reflux disease. Results confirmed no significant difference between groups . Gonmparison of these results show a statistical significance for the incidence of reflux disease in a healthy population, as published in the literature. The gastroesophageal reflux in patients with liver cirrhosis, and esophageal or gastric varices, is more common than in a healthy population. The author suggests a possibility that reflux is one of the reasons for rupture of the varices with sobsequent bleeding. Therefore the followin treatment is indicated total hygene and dietetic regime, abstaining frorn alcohol, sclerotherapy of the varices preventive therapy with propranolol which decreases portal hyypertesion, also preventive therapy with antiacids after meals. Prokinetic cisapride, or antagonists of H2 receptors, or omeprasole are indicated in the treatment of those patients, with liver cirrhosis and esophageal varices, who have the symptoms of reflux disease and/ or pH-metric or endoscopic comfirmed gastroesophageal reflux disease.
Descriptors		DUODENOGASTRIC REFLUX ESOPHAGEAL AND GASTRIC VARICES ESOPHAGEAL DISEASES HYDROGEN-ION CONCENTRATION LIVER CIRRHOSIS HYPERTENSION, PORTAL GASTROINTESTINAL HEMORRHAGE SCLEROTHERAPY ADULT