Author/Editor		Pečovnik-Balon, Breda
Title		Kostne spremembe pri bolnikih, zdravljenih s hemodializo v Splošni bolnišnici Maribor
Translated title		Osseous changes in patients on hemodialysis treatment in Maribor general hospital
Type		članek
Source		In: Pečovnik-Balon B, editor. Zbornik predavanj Strokovni simpozij z mednarodno udeležbo ob 30. obletnici Oddelka za dializo Splošne bolnišnice Maribor; 2004 feb 6-7; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2004
Volume		str. 23-30
Language		slo
Abstract		Background. In our prospective clinical study we measured bone mineral density (BMD) in patients (PTS) beginning haemodialysis treatment (HD). We were interested in the association between BMD and the concentration of intact parathormone (iPTH) and a possible correlation with the basic diseases. Methods. We included 109 PTS (45 women and 64 men). BMD was measured by quantitative digital radiography (QDR) using a Hologic 2000 Plus device. We measured the cortical bone mineral density (BMDc) at the left femoral neck and trabecular bone mineral density (BMDt) in the region of the lumbosacral spine. iPTH was measured by Allegro Intact PTH Imunoassay. ResuIts.The average BMDc (g/cm2) was statistically significant lower than BMDt (P<0.001) in all PTS, PTS with chronic glomerulonephritis had a statistically significantly higher BMDc than those with analgetic nephropathy, (P<0.006). PTS with analgetic nephropathy have higher iPTH than the rest of the PTS (P<0.02) and lower BMDc (p<0.001). During the follow-up of 42.8±25.3 months 19 PTS died, 11 (57.8%) of them of cardiovascular (CV) causes. According to Cox regression analysis association between BMDc and all deaths (R=-0.147;P<0.02) was found. We also found association between BMDc and CV mortality (R=-0.18; P<0.03). Conclusion. Because BMD decreases prior to HD treatment and since association with mortality was found, it is very important to treat this PTS. National Kidney Foundation (NKF) treatment guidelines are presented.
Descriptors		KIDNEY FAILURE, CHRONIC HEMODIALYSIS BONE DENSITY PARATHYROID HORMONES FEMUR NECK LUMBAR VERTEBRAE RENAL OSTEODYSTROPHY CARDIOVASCULAR DISEASES